Vol. 81 No: 3

Title:
Enhanced production of bioactive ginsenosides from adventitious roots of Panax ginseng in bioreactor culture

Authors:
G. SIVAKUMAR, K.W. YUK and K.Y. PAEK

pp: 549-552

Abstract:
Panax ginseng C.A. Meyer roots are highly prized in international markets for their medicinal properties. The present study focussed on the enhanced production of the bioactive anti-cancer protopanaxatriol group of ginsenosides in adventitious roots of P. ginseng in bioreactor cultures by feeding the biogenetic precursor, squalene. HPLC-MS analysis of the saponin fraction indicated higher accumulation of the protopanaxatriol group of ginsenosides (Rg₁ 0.96 mg g^-1, Rg₂ 0.09 mg g^-1 and Re 1.91 mg g^-1 DW) in 40 d-old squalene-fed adventitious roots compared to controls. The results allow predictions of the biosynthetic pathway from squalene to ginsenosides in adventitious roots.

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